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̩ɽҽѧԺʿڹڿGPCRо³ɹ

A-A+20174109:41ɽ

գɽ̩ɽҽѧԺ˽⵽̩ɽҽѧԺʿλNatureӿNature Communications(2016Ӱ11.329)߷оɹArrestin biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling(ѪܽͨArrestinTRPC3ͨżٽصļԷڡ)ʾGPCRµĹģʽоַչѪܽΦ-arrestin-2͵ƫпܷչΪõѪܵҩ

Gż(GPCR)ǷdzҪҩе㣬30%ٴҩֱӰе㶼GPCRΪGPCRҩоеҪԣоѾ10ŵȻGPCRźתڻƺģʽ𲽽ʾĹС

ͳĹ۵ΪGPCRźתʱ࣬һźG׽鵼һϸĤ϶ҷȽϿ(2)ڶźɾнArrestin鵼һ㷢ϣȽ(5Ժ)ڶԽ2ٴҩTRV027оʱ֣нArrestinѪܽ弤ʱֱżTRPC3鵼صļԷ(1)һоִGPCRĹʶ˵G׿ͨͨż鵼GPCRĵһźţArrestinҲͨżϸĤϽ鵼ٵGPCRźšһѪܽεArrestinЦ-arrestin-1;Dzģ-arrestin-2ź;ġһʾGPCRµĹģʽ˵չѪܽΦ-arrestin-2͵ƫпܷչΪõѪܵҩ

ʿɽѧﻯѧѧϵʿΪIJеһߣ̩ɽҽѧԺΪڶɵλɽѧﻯѧѧϵΪͨѶߡ

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